【英文标准名称】:StandardTestMethodforImmunologicalMeasurementofFourPrincipalAllergenicProteins(Hevb1,3,5and6.02)inNaturalRubberandItsProductsDerivedfromLatex
【原文标准名称】:天然橡胶及其胶乳衍生物中4种主要过敏蛋白质(Hevb1,3,5和6.02)免疫学测量的试验方法
【标准号】:ASTMD7427-2008e1
【标准状态】:现行
【国别】:美国
【发布日期】:2008
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:D11.40
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:过敏原
【英文主题词】:allergens;Heveabrasiliensis;IEMA;immunoenzymetricassay;naturalrubberlatex;proteins;Allergens;Naturalrubber(NR);Naturalrubber(NR)latex;Proteins
【摘要】:IgE-mediatedallergicreactionstoproteinallergensinnaturalrubberlatexderivedfromtheHeveabrasiliensistreeemergedinthe1990sasaconcernwithoccasionalallergicmanifestations.Symptomsencompassinghives,uriticaria,rhinitis,asthmaandanaphylaxishaveallbeenreportedinlatexallergicindividualsexposedtoproductsderivedfromnaturalrubberlatex.SincenosafelevelofHevealatexallergenexposureisknown,avoidanceistheprimarymodeoftreatinglatexallergy.Asaresultofinvestigationsconductedbymanyscientistsacrosstheworld,thirteenlatexallergenshavesofarbeenidentifiedandcategorizedbytheAllergenNomenclatureSub-CommitteeoftheInternationalUnionofImmunologicalSocieties(IUIS)asHevb1toHevb13(Table1)(seeSpecificationD1193).ReportedsensitizationratesfortheseallergenicHevbproteinsvaryamongthemanyreportsasaresultofdifferencesinthestudypopulations,IgEantibodyassaymethodsandthequalityoftheHevballergensusedascalibratorsandqualitycontrolreagentsintheanalysis.Moststudies,however,agreethatHevb1andHevb3areimportantallergensforindividuals(forexample,childrenwithspinabifida)whoareexposedthroughmucosalcontactasaresultofmultiplesurgeriesorlatexcatheteruseforanextendedperiodoftime.Additionally,investigatorsperformingsensitizationstudiesalsoagreethatHevb5andHevb6.02areimportantallergensthatmayelicitsensitizationingenetically-predisposedindividualswhoareexposedtonaturalrubberlatex(2-4).Onthebasisoftheseclinicalstudies,assaysforthesefourallergenicproteins(thatis,Hevb1,Hevb3,Hevb5andHevb6.02)havebeendevelopedandtheyarethusthesubjectofthisstandard.Adoptionofimmunoenzymetricassayreagentsandstandardproteinsneededtoquantifyotherlatexallergens(otherthanHevb1,3,5,and6.02)inextractsofnaturalrubberlatexproductswillrequireseparatedocumentationandvalidation.1.1Thistestmethodcoversanimmunologicalmethodknownasanimmunoenzymetricassaytoquantifytheamountof4principalHeveabrasiliensis[Hevb]allergenicproteins[Hevb1,Hevb3,Hevb5andHevb6.02]innaturalrubberanditsproductsderivedfromlatexusingmonoclonalantibodiesspecificforepitopesontheseproteins.Sincetheseassaysquantifythelevelsofonly4oftheknown13officiallyacknowledgedallergenspotentiallypresentinnaturalrubberlatexcontainingproducts,thesumofthefourallergenlevelsshallbeviewedasanindicatoroftheallergenburdenandnotasameasureofthetotalallergencontentthatcanbereleasedfromtheproduct.1.2Forthepurposeofthistestmethod,therangeofallergenicproteinwillbemeasuredintermsofnanogramtomicrogramquantitiespergramorunitsurfaceareaofanaturalrubbercontainingproduct.1.3ThetestmethodisnotdesignedtoevaluatethepotentialofnaturalrubbercontainingmaterialstoinduceorelicitTypeI(IgE-mediated)hypersensitivityreactions.1.4Thistestmethodshouldbeusedundercontrolledlaboratoryconditionstodetectandquantifythelevelof4allergenicproteinsfoundinnaturalrubbercontainingproducts.Itshouldnotbeusedtodescribe,appraiseorassessthehazardorriskofthesenaturalrubbercontainingmaterialsorproductsunderactualinuseconditions.1.5ThevaluesstatedinSIunitsaretoberegardedasstandard.Nootherunitsofmeasurementareincludedinthisstandard.1.6Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Iti......
【中国标准分类号】:B72
【国际标准分类号】:83_060
【页数】:16P.;A4
【正文语种】:英语


【英文标准名称】:Connectorsetsandinterconnectcomponentstobeusedinopticalfibre-Communicationsystems-Productspecifications-Part9-2:TypeMT-RJterminatedonIEC60793-2categoryB1.1singlemodefibre;GermanversionEN50377-9-2:2004
【原文标准名称】:光纤通信系统中使用的连接器组和互连元件.产品规范.第9-2部分:终接在IEC60793-2B1.1类单模光纤上的MT-RJ型
【标准号】:EN50377-9-2-2004
【标准状态】:现行
【国别】:
【发布日期】:2004-09-01
【实施或试行日期】:2004-09-01
【发布单位】:欧洲标准学会(EN)
【起草单位】:
【标准类型】:()
【标准水平】:()
【中文主题词】:设计;尺寸;作标记;试验;电气工程;紧固件;连接;规范;测量技术;电子设备及元件;产品规范;规范(验收);数据传送;寿命;材料;纤维光学;光波导;分规范;玻璃纤维电缆;电插头;可靠度;型式;电子工程;定义;数据连接系统;光电子学;质量保证;单模纤维;工作性能;多模纤维;覆层;产品标准;总论;通信系统;测量;类别
【英文主题词】:Categories;Coatings;Communicationsystems;Connections;Datalinksystem;Datatransfer;Definition;Definitions;Design;Dimensions;Electricplugs;Electricalengineering;Electronicengineering;Electronicequipmentandcomponents;Fasteners;Fibreoptics;Generalsection;Glassfibrecables;Life(durability);Marking;Materials;Measurement;Measuringtechniques;Monomodefibres;Multimodefibres;Opticalwaveguides;Optoelectronics;Performanceinservice;Productspecifications;Productstandards;Qualityassurance;Reliability;Sectionalspecification;Specification;Specification(approval);Testing;Types
【摘要】:
【中国标准分类号】:L23
【国际标准分类号】:33_180_20
【页数】:29P.;A4
【正文语种】:英语